Diagnostic challenge between Crohn's disease and intestinal tuberculosis in chronic diarrhea with ulcerated jejunal stenosis: a case report / Desafío diagnóstico entre la enfermedad de Crohn y la tuberculosis intestinal en la diarrea crónica con estenosis yeyunal ulcerada: reporte de un caso

ABSTRACT Intestinal tuberculosis and Crohn's disease are a diagnostic challenge because of the clinical, radiological and endoscopic similarity. The histological and microbiological findings are positive in less than 50%, which delays the correct treatment, putting the patient at risk. We reported a 34-year-old immunocompetent patient with 4 years of malabsorptive diarrhea, weight loss, nocturnal diaphoresis, abdominal pain and an ulcer with stenosis in the jejunum was found; she received empirical anti- tuberculosis treatment with clinical improvement. Later the culture was positive for M. tuberculosis.

RESUMEN La tuberculosis intestinal y la enfermedad de Crohn son un desafío diagnóstico debido a la similitud clínica, radiológica y endoscópica. Los hallazgos histológicos y microbiológicos son positivos en menos del 50%, lo que retrasa el correcto tratamiento, poniendo en riesgo al paciente. Reportamos un paciente de 34 años inmunocompetente con 4 años de diarrea malabsortiva, pérdida de peso, diaforesis nocturna, dolor abdominal y se encontró una úlcera con estenosis en yeyuno; recibió tratamiento empírico antituberculoso con mejoría clínica. Posteriormente el cultivo fue positivo para M. tuberculosis.

Apendicitis aguda perforada secundaria a una tuberculosis como causa de sepsis posparto / Acute perforated appendicitis secondary to tuberculosis as a cause of postpartum infection

Resumen La tuberculosis gastrointestinal es una manifestación extrapulmonar poco frecuente, correspondiendo al 3% de los casos y que compromete principalmente la región ileocecal; la afectación apendicular es poco frecuente. La apendicitis tuberculosa se puede presentar como un cuadro agudo indistinguible de las otras causas de apendicitis y el diagnóstico generalmente se hace por el hallazgo histopatológico, lo que retrasa el tratamiento y puede llevar a complicaciones. El período posparto es de riesgo de una reactivación de una tuberculosis, debido a cambios en el sistema inmunológico que se manifiestan como un síndrome de reconstitución inmune. Se presenta el caso de una paciente puérpera que ingresa por un choque séptico secundario a una apendicitis perforada. La histopatología demostró una inflamación granulomatosa crónica, con posterior confirmación por biología molecular de una tuberculosis pulmonar.

Abstract Gastrointestinal tuberculosis is a rare extrapulmonary manifestation, it represents 3% of cases and mainly involves the ileocecal region; appendiceal involvement is rare. Tuberculous appendicitis can present as an acute condition indistinguishable from other causes of appendicitis and the diagnosis is generally made by histopathological finding, which delays treatment and can lead to complications. The postpartum period is at risk of a reactivation of tuberculosis, due to changes in the immune system that manifests as an immune reconstitution syndrome. We present the case of a postpartum patient admitted for septic shock secondary to perforated appendicitis, the pathology reported chronic granulomatous inflammation and subsequent confirmation by molecular technique of pulmonary tuberculosis.

Tuberculosis gastrointestinal como causa de hemorragia digestiva masiva en un paciente con infección por VIH / Gastrointestinal tuberculosis as a cause of massive gastrointestinal bleeding in a patient with HIV infection

Resumen La tuberculosis (TBC) gastrointestinal es una complicación infrecuente y fatal en pacientes con infección por VIH. Se presenta en 3-16% de las formas extrapulmonares y su principal localización es la válvula ileocecal y colon. La hemorragia digestiva baja con presencia de una o múltiples úlceras en colon es una presentación muy inusual de TBC intestinal. El diagnóstico se confirma por biopsia y cultivo del tejido intestinal. La cirugía en caso de perforación intestinal sigue siendo el tratamiento de elección. Se presenta el caso de un paciente con infección por VIH, sin tratamiento anti-retroviral, quien desarrolló una TBC diseminada con perforación intestinal y hemorragia digestiva masiva de curso fatal.

Gastrointestinal tuberculosis is a rare and fatal complication in patients with HIV infection. It occurs in 3%-16% of extra pulmonary forms. The main location in 90% of cases is the ileocecal valve and colon. The most unusual presentation of gastrointestinal tuberculosis is massive bleeding with the presence of one or multiple ulcers in the colon. The diagnosis can be confirmed by biopsy and by culture of intestinal tissue. Surgical resection is the treatment of choice. We report a case of a HIV-infected patient, who did not receive antiretrovirals, and who developed disseminated tuberculosis with intestinal perforation, presenting a fatal massive intestinal bleeding.

Absceso intrabdominal secundario a tuberculosis intestinal en el Hospital General Dolisie de la República del Congo / Intra-abdominal abscess secondary to intestinal tuberculosis in general hospital Dolisie, Republic of Congo

La incidencia de TB intestinal es desconocida, ya que puede ser asintomática y por su naturaleza a menudo resulta en diagnósticos erróneos, por lo que se debe tener un alto índice de sospecha en poblaciones de alto riesgo. Los abscesos intrabdominales en el curso de esta es una complicación poco frecuente, con una incidencia entre 2 y 30 por ciento. Presentamos un paciente masculino de 52 años de edad, con masa abdominal en mesogástrio, asociada a dolor abdominal y pérdida de peso. Se comienza su estudio con Rx. de tórax y ecografía abdominal, el cual reporta masa de 90 x 47 mm en el peritoneo, es intervenido quirúrgicamente y drenado por absceso intrabdominal. Se diagnostica TB intestinal, su evolución fue satisfactoria después de iniciado el tratamiento antituberculoso. Ante un paciente con síntomas de abdomen agudo, es importante realizar un diagnóstico temprano de TB intestinal. Esto evitaría una intervención innecesaria, porque el diagnóstico de la TB intestinal es médico. Si se realiza la intervención, puede confirmarse el diagnóstico mediante las lesiones encontradas; acción que impediría una resección intestinal innecesaria pues el tratamiento antituberculoso resolvería la TB. Generalmente, el diagnóstico se realiza durante una cirugía o por procedimientos invasivos con otros propósitos, por ser esta de difícil diagnóstico clínico y que la irregularidad del tratamiento antituberculoso es un importante factor de riesgo para el desarrollo de complicaciones en la TB intestinal diagnosticada. Esta es altamente efectivo en la resolución de complicaciones de moderada gravedad como la obstrucción intestinal y los abscesos intrabdominales(AU)

The incidence of intestinal tuberculosis is unknown since it may be symptom-free and lead to frequent misdiagnoses, so one should highly suspect of intestinal tuberculosis in high risk populations. The intra-abdominal abscesses are rare complications, with an incidence rate of 2 to 30 percent. Here is the case of a 52 years-old male patient who had an abdominal in her mesogastrium associated to abdominal pain and weight loss. The first testing was thorax X-ray and abdominal ultrasound, which revealed the presence of a 90x74mm mass in the peritoneum. As a result, he was operated on including intrabdominal abscess drainage. The final diagnosis was intestinal tuberculosis, being the recovery satisfactory after the anti-tuberculosis treatment. It is fundamental to make emphasis on the importance of early diagnosis of intestinal tuberculosis in patients with acute abdomen symptoms in risk groups since this may avoid surgical treatment. The diagnosis based on macroscopic findings in case of surgical treatment may also avoid unnecessary intestinal resections. Generally speaking, the diagnosis is made during a surgery or by invasive procedures with other purposes since the clinical diagnosis is difficult; irregular anti-tuberculosis treatment is a significant risk factor for the development of complications in diagnosed intestinal tuberculosis. It is highly effective in the resolution of moderate-severity complications such as intestinal obstruction and intra-abdominal abscesse(AU)

Compromiso intestinal por Mycobacterium avium en un paciente con VIH/ SIDA / Intestinal disease due to Mycobacterium avium in a patient with HIV/AIDS

amos el primer caso de colitis por Mycobacterium avium en un paciente peruano con infección por VIH /SIDA.

We report the first case of colitis due to Mycobacterium avium in a Peruvian patient with HIV/AIDS.

An Interesting Case of Tuberculous Colitis Mimicking Crohn's Disease.

Intestinal tuberculosis is a rare disease in western countries and may mimic a variety of gastrointestinal disorders. Here, we report the case of a 29-yr-old male patient who presented with loose motions, loss of appetite and loss of body weight since two years. On colonoscopy transverse colon, ascending colon, caecum and ileocaecal mucosa was inflamed, swollen and showed multiple superficial longitudinal ulcerations. Crohn’s disease was suspected based on colonoscopic finding. However histopathological examination of biopsies from colonic mucosa then revealed caseating granulomas in the colonic mucosa typical for mycobacterium tuberculosis infection. Our diagnosis is supported by raised serum IgM levels.The patient responded nicely to antitubercular therapy. This case emphasizes the need to include intestinal tuberculosis in the initial differential diagnosis of ulcerative colorectal lesions.

Tuberculosis of Rectum simulating malignancy and presenting as rectal prolapse - A case report and review.

Summary: Tuberculosis of the gastrointestinal tract (GIT) occurs as a primary lesion or secondary to a focus of tuberculosis elsewhere in the body, most commonly in the lungs. Tuberculosis can affect any part of the GIT from the oesophagus to the anal canal. Two main types are – the tuberculous ulcer and the rarer hypertrophic type which is generally found at the ileocecal junction, less commonly in the colon or rectum. Tuberculosis of bowel distal to ileocecal junction is rare and is seldom considered as a differential diagnosis of rectal stricture (2%).1,6 We report a case of rectal tuberculosis presenting with rectal prolapse and masquerading as malignancy, clinically, radiologically as well as on colonoscopy. The diagnosis was confirmed by repeated histopathological examination. The patient underwent definitive surgery along with anti-tuberculous therapy.

Tuberculosis colónica. Presentación de caso / Colonic tuberculosis. Report of a case

Introducción: la tuberculosis es una enfermedad conocida desde la antigüedad, causada por el Mycobacterium Tuberculosis. En las últimas décadas hubo un resurgimiento de la patología, debido a la infección por HIV. La tuberculosis gastrointestinal representa del 3 al 5% de todos los casos de localización extrapulmonar. Objetivo: evaluar el comportamiento de una patología infrecuente del colon, a partir de un caso clínico. Material y método: paciente masculino de 50 años, operado, con diagnóstico anatomopatológico de tuberculosis colónica. Resultados: se realizó colectomía derecha, por hemorragia digestiva baja grave. Conclusiones: es una entidad poco frecuente, que raramente involucra el colon. El compromiso gastrointestinal es la sexta forma más frecuente de tuberculosis extrapulmonar. La región ileocecal, es la que se encuentra mas afectada. El tratamiento es médico, la cirugía se reserva para las complicaciones de la entidad.

Background: tuberculosis is a disease known since antiquity, caused by Mycobacterium tuberculosis. In recent decades there has been a resurgence of the disease due to HIV infection. The gastrointestinal tuberculosis represents 3 to 5% of extrapulmonary cases. Purpose: to evaluate the behavior of a rare pathology of the colon, from a clinical case. Material and Methods: male patient, 50 years old, diagnosed with colonic tuberculosis, who underwent surgery. Results: right colectomy for severe low gastrointestinal bleeding. Conclusions: it is a rare entity, which rarely involves the colon. The gastrointestinal involvement is the sixth most common form of extrapulmonary tuberculosis. The ileocecal region, is the most affected. The treatment is medical, with surgery reserved for complications of the entity.

Spectrum of malabsorption syndrome among adults & factors differentiating celiac disease & tropical malabsorption.

Background & objectives: Aetiology of malabsorption syndrome (MAS) differs in tropical and temperate countries over time; clinical and laboratory parameters may differentiate between various causes. This study was undertaken to investigate the spectrum of MAS among Indian adults and to find out the features that may help to differentiate between TM and celiac disease. Methods: Causes of MAS, and factors differentiating tropical malabsorption (TM) from celiac disease (CD) were determined in 275 patients. Results: Using standard criteria, causes in 275 patients [age 37.5+13.2 yr, 170, (61.5%) male] were, TM 101 (37%), CD 53 (19%), small intestinal bacterial overgrowth 28 (10%), AIDS 15 (5.4%), giardiasis 13 (5%), hypogammaglobulinemia 12 (4%), intestinal tuberculosis 7 (2.5%), strongyloidiasis 6 (2%), immunoproliferative small intestinal disease 5 (2%), Crohn's disease 6 (2%), amyloidosis 4 (1.5%), intestinal lymphangiectasia 3 (1%) and unknown 22 (8%). On univariate analysis, patients with CD were younger than TM (30.6+12 vs. 39.3+12.6 yr, P<0.001), had lower body weight (41.3+11.8 vs. 49.9+11.2 kg, P<0.001), longer diarrhoea duration (median 36 inter-quartile range 17.8-120 vs. 24-months, 8-48, P<0.01), lower stool frequency (6/day, 5-8 vs. 8, 5-10, P<0.05), lower haemoglobin (9.4+3.2 vs. 10.4+2.7 g/dl, P<0.05), higher platelet count (2,58,000, range 1,35,500-3,23,500 vs. 1,60,000, 1,26,000-2,58,000/mm3, P<0.05), and more often had hepatomegaly (9/53, 17% vs. 4/101, 4%, P<0.01), and subtotal or partial villous atrophy (36/50, 72% vs. 28/87, 32%, P<0.001). Younger age (<35 yr), longer diarrhoea duration, higher platelet count and villous atrophy were significant on multivariate analysis. Interpretation & conclusions: TM and CD are common causes of MAS among Indian adults. Younger age (<35 yr), longer diarrhoea duration, higher platelet count and villous atrophy were found to be associated with CD.

Blastomicosis oral, papilomatosis laríngea y tuberculosis esofágica / Oral blastomycosis, laryngeal papillomatosis and esophageal tuberculosis

El compromiso esofágico es una complicación infrecuente de la tuberculosis incluso en países con alta prevalencia de infección. Se presenta el caso de un paciente de 57 años no seropositivo al virus de inmunodeficiencia humana (VIH), con diagnóstico simultáneo de blastomicosis en cavidad oral y papilomatosis laríngea, ambas confirmadas por anatomía patológica. La biopsia de esófago reveló esofagitis granulomatosa con necrosis; la tinción de Ziehl-Neelsen mostró bacilos ácido-alcohol resistente, sugerentes de tuberculosis. El antecedente de tuberculosis pulmonar en dos oportunidades y abandono de tratamiento determinó el inicio de tratamiento antituberculoso de segunda línea a través de un tubo de gastrostomía, más itraconazol vía oral. La evolución fue favorable.

Esophageal involvement is an extremely rare complication of tuberculosis even in countries with high prevalence of infection. We report the case of a 57 year-old hiv-seronegative patient with simultaneous diagnoses of oral blastomycosis and laryngeal papillomatosis. Both were confirmed by anatomopathological analysis. The esophageal biopsy revealed granulomatous esophagitis with necrosis and ziehl-neelsen stain showed acid-fast alcohol resistant bacilli suggestive of tuberculosis. The patient’s history included pulmonary tuberculosis twice and previous abandonment of therapy. Thus, it was necessary to use oral itraconazole combined with second-line anti-tuberculosis drugs administered through a gastrostomy tube. The clinical development was favorable.

Laparoscopic assisted right hemicolectomy. An experience of laparoscopic assisted right hemicolectomy in benign disease -- tuberculosis

To assess the outcome of laparoscopic assisted right hemicolectomy in benign diseases like tuberculosis. Prospective observational study. Surgical unit-I of Jinnah Hospital Lahore. Jan 2009 and June 2010. This study included a series of twenty patients with preoperative clinical diagnosis of ileocecal tuberculosis. A three trocar technique was used to perform laparoscopic right hemi colectomy and anastomosis was performed outside the abdomen by extending the supraumbilical incision. Data of 20 patients who underwent laparoscopic assisted right hemicolectomy was analyzed. Mean age of the patients was 27.5 years with male to female ratio 4:1 [Table-I]. There was zero conversion [0%] to open surgery and no intra-operative complications [0%] were observed. Average hospital stay was 5.8 days. No patients had to be re operated. On histopathology of specimen final diagnosis was 95% ileo cecal tuberculosis and one patients [5%] turned out to be having lymphoma [Table-III]. The laparoscopic colon surgery can produce excellent results in selected patients of abdominal tuberculosis. Advantages of laparoscopic over open surgery include less postoperative pain, short-term postoperative ileus, earlier return to daily activity

Úlcera tuberculosa intestinal como causa de hemorragia digestiva baja masiva exanguinante / Intestinal tuberculosis causing a severe gastrointestinal bleeding: report of one case

We report a 27 years old woman presenting with hematochezia. An upper endoscopy and colonoscopy did not reveal the bleeding site. Due to persistence of bleeding, the patient was operated, finding a fibrinous secretion surrounding bowel loops and a hyper vascularized concentric papular lesion. The involved bowel loop was excised. The pathological study of the surgical piece revealed intestinal tuberculosis. The patient started treatment for extra pulmonary tuberculosis.

Reportamos el caso de una paciente de 27 años con tuberculosis extrapulmonar gastrointestinal que se manifestó clínicamente como una hemorragia digestiva baja masiva exanguinante requiriendo cirugía de urgencia, donde se realizó laparotomía exploradora con entero y colonoscopía intraoperatoria localizando lesión a nivel de intestino delgado, resecando segmento comprometido con anastomosis primaria, evolución satisfactoria sin complicaciones postoperatorias.

Ultrasonography for diagnosis of abdominal tuberculosis in HIV infected people.

Background & objectives: There is an increasing incidence of abdominal tuberculosis with the advent of HIV infection. This study was aimed at determining the pattern of presentation of abdominal tuberculosis on ultrasonography (USG) in HIV positive patients. Methods: This retrospective study was carried at the ART Centre, Sir Sunderlal Hospital, Banaras Hindu University, Varanasi, between March 2005 to July 2007. HIV positive patients (n=2453) with prolonged fever, abdominal pain/distension, altered bowel habits and diarrhoea underwent ultrasonography for tuberculosis of abdomen. The different ultrasonological findings in abdominal tuberculosis were noted. CD4 counts of these patients were also recorded. Results: Of the total 2453 patients, 244 showed findings suggestive of abdominal tuberculosis. Lymphadenopathy with predominantly hypoechoic/necrotic echotexture was seen in 158/244 (64.8%) patients. Splenomegaly was seen in 68 patients with 61 of them (89.7%) showing multiple hypoechoic lesions in the parenchyma. 53 of 244 (21.7%) showed extensive abdominal involvement. Liver enlargement was seen as a part of extensive abdominal involvement. A total of 203 patients completed antitubercular treatment, of which 198 (97.5%) showed resolution of lesions in USG. CD4 counts in patients with extensive abdominal involvement were lowest compared to CD4 count in patients with others USG findings. Interpretation & conclusion: Ultrasonological findings like lymphadenopathy (≥1.5 cm) with hypoechoeic/necrotic echotexture, hypoechoic splenic lesions and extensive abdominal involvement in HIV infected patients may be suggestive of abdominal tuberculosis.

Tuberculosis abdominal en pacientes con VIH/SIDA / Abdominal tuberculosis in a patient With HIV/AIDS

Introducción. La tuberculosis abdominal cursa con un cuadro inespecífico, con difícil diagnóstico diferencial respecto a otras entidades de similar semiología. Caso clínico. Presentamos el caso de un varón que ingresa por dolor abdominal, pérdida progresiva y notoria de peso corporal y fiebre de un mes de evolución, al examen físico se encuentra masa abdominal de la cual se obtiene material denso-purulento que al Ziehl Neelsen demostró la presencia de bacilo alcohol acido resistente. La prueba de VIH fue positiva. Conclusión. El caso ilustra una forma de presentación de la tuberculosis abdominal en paciente inmunosupreso...

Ulceración perianal: Dos casos de una rara manifestación de tuberculosis extrapulmonar / Perianal tuberculosis: Report of two cases

Perianal tuberculosis is an uncommon variant of extra pulmonary tuberculosis and mimics other common perianal conditions. We report two patients with perianal tuberculosis. An 82-year-old male presenting with purulent perianal discharge and weight loss. A pelvic magnetic resonance imaging showed a low trans sphincteric anorectal fistula with abscess formation. A fistulectomy was performed and the pathological study showed a granulomatous-tuberculous chronic inflammation. Mycobacteria were recovered from gastric contents. A 48-year-old male with the same symptoms. An ulcerated lesion in the anal region was biopsied, disclosing a granulomatous inflammatory process with Ziehl-Nielsen stainable organisms.

Incidence of abdominal tuberculosis in 186 cases of acute abdomen presenting in our surgical emergency department

Among 186 cases of Acute Abdomen, determining the frequency of abdominal tuberculosis patients with their outcome. A prospective case study from January, 2009 to June 2010. Surgical Unit-V District Headquarters [Teaching] Hospital, Faisalabad. Detailed data of each patient including presentation, operative findings, procedure performed, post operative outcome and histopathology was entered on a specially designed Performa, compiled and analyzed. During the period of study, 186 patients presented in the surgical emergency with complaints of acute abdomen out of which 54 [29.03%] were of abdominal tuberculosis. Mean age of presentation was 27.3 years. Operative findings showed predominance of ileocaecal hypertrophic tuberculosis [tuberculous mass] in 18 [33.33%] patients, followed by tuberculous adhesions, ileal strictures and plastic gut.The surgical procedures were performed according to their intra-abdominal findings out of which right hemicolectomy with ileocolic end to end anastomosis in 18 [33.33%] patients remained the commenest procedure performed followed by segmental ileal resection anastomosis, ileostomy and stricturoplasty. 20 [37.04%] patients reported to have post-operative complications in which wound infection in 7 [12.96%] remained the highest occurring postoperative complication followed by intra-abdominal collection, anastomotic leakage and septicemia. Mortality rate among the patients of abdominal tuberculosis in this study remained 5.56%. Complicated abdominal tuberculosis is the most common pathology of acute abdomen. By proper management of pre-complicated abdominal tuberculosis, this disastrous stage of disease resulting in so morbidity and mortality can be reduced